| Spinal Remains Pumpkin Stout | Spring House Brewing Company | Pumpkin Beer | 8.5% |
| Spine Tingler | Portland Brewing | Tripel | |
| Spinnerfall Saison | Fall River Brewery | Saison | 5.4% |
| Spinning Mule | Cedar Creek Brewery | American Porter | 7.1% |
| Spiral Jetty | Epic Brewing Company | American IPA | 6.6% |
| Spirit Beast | Jackie O's Pub & Brewery | American Strong Ale | 11.0% |
| Spirit of Danny | Rockyard Brewing | Saison | 8.4% |
| Spirit of Skully #1 Barleywine | Paradox Beer Company | American Barleywine | 15.5% |
| Spiteful IPA | Spiteful Brewing Company | American IPA | 6.2% |
| Spitfire | Santiam Brewing Company | Extra Special / Strong Bitter (ESB) | 6.2% |
| Spitfire Best Bitter | Flyers Restraunt and Brewery | English Bitter | 4.0% |
| Spitfire Premium Kentish Strong Ale | Shepherd Neame | | 4.5% |
| Splinter Black | Troegs Brewing | American Imperial Stout | 11.0% |
| Splinters | Black Raven Brewing Co. | | |
| Split Decision | RoughTail Brewing Company | Rye Beer | 8.9% |