| Spruce Ale | Siletz Roadhouse & Brewery | | |
| Spruce Creek Lager | Otto's Pub and Brewery | American Lager | 4.8% |
| Spruce Desay | De Garde Brewing | | |
| Spruce Pilsner | Short's Brewing Company | | |
| spruce tip ipa | Lawson's Finest Liquids | | |
| Spruce Tipped | Blacklist Beer LLC | Imperial IPA | 9.5% |
| Spruced Traditional Gose | Freigeist Bierkultur | Gose | 5.0% |
| Sprung | 5 Stones Craft Brewing | | 6.2% |
| Sprung | Evolution Craft Brewing Company | American Blonde Ale | 4.9% |
| Sprye | MadTree | Rye Beer | 5.0% |
| Sputnik | Wellington Brewery | | |
| Squall IPA | Dogfish Head Craft Brewery | Imperial IPA | 9.0% |
| Square Feet Wheat | Bavarian Barbarian Brewing Company | | |
| Squashed | Mother's Brewing Company | Pumpkin Beer | 7.4% |
| Squatters Hell's Keep | Utah Brewers Cooperative | Belgian Pale Strong Ale | 7.8% |