| Brewery | Location |
|---|---|
| Southern Prohibition Brewery | Hattisburg |
| Southern Star Brewing Company | Conroe, Texas |
| Southern Tier Brewing Co | Lakewood, New York |
| Spanish Peaks Brewing | Polson, Montana |
| Spaten-Franziskaner-Bräu | München, Germany |
| Speakeasy Ales and Lagers | San Francisco, California |
| Spellbound | Mt. Holly, New Jersey |
| Spencer Brewery | Spencer, Massachusetts |
| Spider Bite Brewing Company | New York |
| Spilker Ales | Cortland, Nebraska |
| Spinnakers Brewpub | Victoria |
| Spitalbrauerei | Regensburg |
| Spiteful Brewing Company | |
| Spoetzl Brewery | Shiner, Texas |
| Spoonwood Brewing Company | Pittsburgh |